许晨，讲师，微生物检验教研室，邮箱: chenxu99916@126.com

【学习工作经历】

2022.3 - 至今，威尼斯澳门人登录welcome，讲师

2021.9 - 2022.1，香港城市大学，研究助理

2016.9 - 2021.9，香港理工大学，生命科学，博士

2015.7 - 2016.8，香港理工大学，研究助理

2011.09 - 2015.05，中山大学与香港理工大学联合培养，化学，学士

【教改科研项目】

深圳2020年基础研究重点项目，项目编号R-BTC8001e，2020.11.24-2023.11.30，参与

【代表性论文】

1. Yue, K. #, Xu, C. #, Wang, Z., Liu, W., Liu, C., Xu, X., ... & Wan, S. (2022). 1,2-Isoselenazol-3 (2H)-one derivatives as NDM-1 inhibitors displaying synergistic antimicrobial effects with meropenem on NDM-1 producing clinical isolates. Bioorganic Chemistry, 106153. (#共一)

2. Xu, C., Liu, C., Chen, K., Zeng, P., Chan, E. W. C., & Chen, S. (2022). Otilonium bromide boosts antimicrobial activities of colistin against Gram-negative pathogens and their persisters. Communications biology, 5(1), 1-11.

3. Xu, C., Dong, N., Chen, K., Yang, X., Zeng, P., Hou, C., ... & Chen, S. (2022). Bactericidal, anti-biofilm, and anti-virulence activity of vitamin C against carbapenem-resistant hypervirulent Klebsiella pneumoniae. Iscience, 25(3), 103894.

4. Jin, W. B.#, Xu, C.#, Qi, X. L., Zeng, P., Gao, W., Lai, K. H., ... & Chan, K. F.(2021). Synthesis of 1, 3, 4-trisubstituted pyrrolidines as meropenem adjuvants targeting New Delhi metallo-β-lactamase. New Journal of Chemistry, 45(7), 3515-3534. (#共一)

5. Xu, C., Chen, K., Chan, K. F., Chan, E. W. C., Guo, X., Chow, H. Y., ... & Li, X. Imidazole Type Antifungal Drugs Are Effective Colistin Adjuvants That Resensitize Colisti‐Resistant Enterobacteriaceae. Advanced Therapeutics, 2000084.

6. Jin, W. B.#, Xu, C#., Cheung, Q., Gao, W., Zeng, P., Liu, J., ... & Chen, S. (2020).Bioisosteric investigation of ebselen: synthesis and in vitro characterization of 1, 2-benzisothiazol-3 (2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors. Bioorganic Chemistry, 103873. (#共一)

7. Cheng, Q. #, Xu, C. #, Chai, J., Zhang, R., Wai chi Chan, E., & Chen, S. (2019). Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution. ACS Infectious Diseases, 6(4), 577-587. (#共一)

8. Jin, W. B. #, Xu, C. #, Cheng, Q., Qi, X. L., Gao, W., Zheng, Z., ... &Chen, S.(2018). Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1, 2-benzisoselenazol-3 (2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1. European journal of medicinal chemistry, 155, 285-302. (#共一)

【专利】

1. Sheng Chen, Chen Xu, United States Patent Application No. 17/862,617 Filed on 12 Jul 2022：DRUG COMPOSITION, METHOD FOR TREATING INFECTION, DISINFECTING COMPOSITION, AND DRUG ADJUVANT